Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity

Martin Frederik Laursen, Louise B. B. Andersen, Kim F. Michaelsen, Christian Mølgaard, Ellen Trolle, Martin Iain Bahl, Tine Rask Licht

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Abstract

The first years of life are paramount in establishing our endogenous gut microbiota, which is strongly affected by diet and has repeatedly been linked with obesity. However, very few studies have addressed the influence of maternal obesity on infant gut microbiota, which may occur either through vertically transmitted microbes or through the dietary habits of the family. Additionally, very little is known about the effect of diet during the complementary feeding period, which is potentially important for gut microbiota development. Here, the gut microbiotas of two different cohorts of infants, born either of a random sample of healthy mothers (n = 114), or of obese mothers (n = 113), were profiled by 16S rRNA amplicon sequencing. Gut microbiota data were compared to breastfeeding patterns and detailed individual dietary recordings to assess effects of the complementary diet. We found that maternal obesity did not influence microbial diversity or specific taxon abundances during the complementary feeding period. Across cohorts, breastfeeding duration and composition of the complementary diet were found to be the major determinants of gut microbiota development. In both cohorts, gut microbial composition and alpha diversity were thus strongly affected by introduction of family foods with high protein and fiber contents. Specifically, intake of meats, cheeses and Danish rye bread, rich in protein and fiber, were associated with increased alpha diversity. Our results reveal that the transition from early infant feeding to family foods is a major determinant for gut microbiota development.
Original languageEnglish
Publication date2016
Number of pages1
Publication statusPublished - 2016
Event10th INRA-Rowett Symposium: Gut Microbiology - Polydome, Place du 1er Mai, Clermont-Ferrand, France
Duration: 20 Jun 201623 Jun 2016
Conference number: 10
https://colloque.inra.fr/inra-rowett-2016/

Conference

Conference10th INRA-Rowett Symposium: Gut Microbiology
Number10
LocationPolydome, Place du 1er Mai
CountryFrance
CityClermont-Ferrand
Period20/06/201623/06/2016
Internet address

Cite this

Laursen, M. F., Andersen, L. B. B., Michaelsen, K. F., Mølgaard, C., Trolle, E., Bahl, M. I., & Licht, T. R. (2016). Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity. Abstract from 10th INRA-Rowett Symposium: Gut Microbiology, Clermont-Ferrand, France.