Industrially useful enzymology: Translating biocatalysis from laboratory to process

Elif Erdem, John M. Woodley*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Biocatalysis is a growing discipline, allowing selective catalysis under mild conditions. In particular, protein engineering offers the potential to change enzyme properties and also offers the discovery of entirely new reactions. For implementation in industry, reaction performance metrics (including reaction yield, productivity, product concentration, and specific yield) need to meet minimum targets in order to be cost effective. An important consequence of this is that enzymes need to work under very different conditions from those usually found in nature. Industrial conditions can include high concentrations of substrate and product, as well as the presence of gas-liquid and liquid-liquid interfaces. Conventional enzymology has focused on understanding enzymes under a relatively narrow range of conditions, but the need now is for a new enzymology focused on industrially relevant conditions. In order to achieve this, new scale-down experiments that can mimic industrial conditions at a laboratory scale will be required.
Original languageEnglish
JournalChem Catalysis
Volume2
Issue number10
Pages (from-to)2499-2505
ISSN2667-1093
DOIs
Publication statusPublished - 2022

Keywords

  • Biocatalysis
  • Enzyme stability
  • New-to-nature conditions
  • Performance metrics
  • Enzyme kinetics
  • Reaction thermodynamics

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