TY - JOUR
T1 - Induction of protein droplet (α2μ-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene
AU - Kristiansen, E.
AU - Madsen, Charlotte Bernhard
PY - 1995
Y1 - 1995
N2 - As part of a series of short-term studies on peppermint oil constituents for their possible induction of the encephalopathy found with peppermint oil, 1,8-cineole and l-limonene were studied. Groups of 10 male Wistar rats were given 0, 500, or 1000 mg 1,8-cineole/kg body wt./day or 0, 800, or 1600 mg l-limonene/kg body wt./day for 2& days. 1,8-Cineole and l-limonene both induced accumulation of protein droplets containing alpha(2 mu)-globulin in proximal tubular epithelial cells in male rats. These results suggest that both 1,8-cineole and I-limonene possibly belong to the group of chemicals characterized by their induction of excessive alpha(2 mu)-globulin accumulation. Neither of the 2 substances induced encephalopathy.
AB - As part of a series of short-term studies on peppermint oil constituents for their possible induction of the encephalopathy found with peppermint oil, 1,8-cineole and l-limonene were studied. Groups of 10 male Wistar rats were given 0, 500, or 1000 mg 1,8-cineole/kg body wt./day or 0, 800, or 1600 mg l-limonene/kg body wt./day for 2& days. 1,8-Cineole and l-limonene both induced accumulation of protein droplets containing alpha(2 mu)-globulin in proximal tubular epithelial cells in male rats. These results suggest that both 1,8-cineole and I-limonene possibly belong to the group of chemicals characterized by their induction of excessive alpha(2 mu)-globulin accumulation. Neither of the 2 substances induced encephalopathy.
U2 - 10.1016/0378-4274(95)03390-7
DO - 10.1016/0378-4274(95)03390-7
M3 - Journal article
SN - 0378-4274
VL - 80
SP - 147
EP - 152
JO - Toxicology Letters
JF - Toxicology Letters
IS - 1-3
ER -