Indoor-outdoor particle effects on health in middle-aged and elderly

Dorina Gabriela Karottki, Gabriel Bekö, Jette G. Hemmingsen, Kim Jantzen, Geo Clausen, Torben Sigsgaard, Peter Møller, Steffen Loft

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Abstract

A series of 5 studies in a total of 300 middle-aged and elderly individuals have related exposure to indoor and outdoor ultrafine and fine particles for 5-48 h to effects on vascular and lung function with possible explanatory inflammation and oxidative stress biomarkers. The data consistently support detrimental effect of UFP from traffic on vascular function. Indoor UFP and PM2.5 might contribute to cardiovascular risk through endothelial damage and vascular dysfunction, respectively, whereas indoor UFP dominated by candle burning appears to have adverse lung effects. The biomarkers provided no mechanistic explanation.
Original languageEnglish
Title of host publicationProceedings of Indoor Air 2016
Number of pages2
Publication date2016
Article number1188
Publication statusPublished - 2016
Event14th international conference on Indoor Air Quality and Climate - Ghent, Belgium
Duration: 3 Jul 20168 Jul 2016
Conference number: 14

Conference

Conference14th international conference on Indoor Air Quality and Climate
Number14
CountryBelgium
CityGhent
Period03/07/201608/07/2016

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