Indole alkaloids and terpenoids from Tabernaemontana markgrafiana

H.B. Nielsen; A. Hazell; R. Hazell; F. Ghia; K.B.G. Torssell

doi:10.1016/S0031-9422(00)89601-6

Indole alkaloids and terpenoids from _Tabernaemontana markgrafiana

H.B. Nielsen, A. Hazell, R. Hazell, F. Ghia, K.B.G. Torssell

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids. The major triterpene was baurenyl acetate, which constituted ca 6% of the crude petrol extract. An X-ray study of iso-ursenyl acetate was carried out for the first time. The indole alkaloids were primarily of the iboga-type and constituted ca 3% of the dried bark and 20% of the total extracts. The major alkaloids were coronaridine, (19S)-heyneanine, voacangine and ibogamine. Among the minor components, four new alkaloids were identified: 5,6-dehydro-coronaridine, 3R-methoxy-coronaridine, 3R-methoxyvoacangine and the 10,11-demethoxy chippiine.

Original language	English
Journal	Phytochemistry
Volume	37
Issue number	6
Pages (from-to)	1729-1735
ISSN	0031-9422
DOIs	https://doi.org/10.1016/S0031-9422(00)89601-6
Publication status	Published - 1994

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title = "Indole alkaloids and terpenoids from Tabernaemontana markgrafiana",

abstract = "The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids. The major triterpene was baurenyl acetate, which constituted ca 6% of the crude petrol extract. An X-ray study of iso-ursenyl acetate was carried out for the first time. The indole alkaloids were primarily of the iboga-type and constituted ca 3% of the dried bark and 20% of the total extracts. The major alkaloids were coronaridine, (19S)-heyneanine, voacangine and ibogamine. Among the minor components, four new alkaloids were identified: 5,6-dehydro-coronaridine, 3R-methoxy-coronaridine, 3R-methoxyvoacangine and the 10,11-demethoxy chippiine. ",

author = "H.B. Nielsen and A. Hazell and R. Hazell and F. Ghia and K.B.G. Torssell",

year = "1994",

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TY - JOUR

T1 - Indole alkaloids and terpenoids from Tabernaemontana markgrafiana

AU - Nielsen, H.B.

AU - Hazell, A.

AU - Hazell, R.

AU - Ghia, F.

AU - Torssell, K.B.G.

PY - 1994

Y1 - 1994

N2 - The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids. The major triterpene was baurenyl acetate, which constituted ca 6% of the crude petrol extract. An X-ray study of iso-ursenyl acetate was carried out for the first time. The indole alkaloids were primarily of the iboga-type and constituted ca 3% of the dried bark and 20% of the total extracts. The major alkaloids were coronaridine, (19S)-heyneanine, voacangine and ibogamine. Among the minor components, four new alkaloids were identified: 5,6-dehydro-coronaridine, 3R-methoxy-coronaridine, 3R-methoxyvoacangine and the 10,11-demethoxy chippiine.

AB - The bark of Tabernaemontana markgrafiana yielded five acetylated pentacyclic triterpenes and 24 monoterpene indole alkaloids. The major triterpene was baurenyl acetate, which constituted ca 6% of the crude petrol extract. An X-ray study of iso-ursenyl acetate was carried out for the first time. The indole alkaloids were primarily of the iboga-type and constituted ca 3% of the dried bark and 20% of the total extracts. The major alkaloids were coronaridine, (19S)-heyneanine, voacangine and ibogamine. Among the minor components, four new alkaloids were identified: 5,6-dehydro-coronaridine, 3R-methoxy-coronaridine, 3R-methoxyvoacangine and the 10,11-demethoxy chippiine.

U2 - 10.1016/S0031-9422(00)89601-6

DO - 10.1016/S0031-9422(00)89601-6

M3 - Journal article

SN - 0031-9422

VL - 37

SP - 1729

EP - 1735

JO - Phytochemistry

JF - Phytochemistry

IS - 6