Indirect rapid prototyping of antibacterial acid anhydride copolymer microneedles

Ryan D. Boehm, Philip R. Miller, Ritika Singh Petersen, Akash Shah, Shane Stafslien, Justin Daniels, Roger J. Narayan

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Microneedles are needle-like projections with microscale features that may be used for transdermal delivery of a variety of pharmacologic agents, including antibacterial agents. In the study described in this paper, an indirect rapid prototyping approach involving a combination of visible light dynamic mask micro-stereolithography and micromolding was used to prepare microneedle arrays out of a biodegradable acid anhydride copolymer, Gantrez® AN 169 BF. Fourier transform infrared spectroscopy, energy dispersive x-ray spectrometry and nanoindentation studies were performed to evaluate the chemical and mechanical properties of the Gantrez® AN 169 BF material. Agar plating studies were used to evaluate the in vitro antimicrobial performance of these arrays against Bacillus subtilis , Candida albicans , Enterococcus faecalis , Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus . Large zones of growth inhibition were noted for Escherichia coli, S. aureus, Enterococcus faecalis and B. subtilis . The performance of Gantrez® AN 169 BF against several bacteria suggests that biodegradable acid anhydride copolymer microneedle arrays prepared using visible light dynamic mask micro-stereolithography micromolding may be useful for treating a variety of skin infections.
Original languageEnglish
JournalBiofabrication
Volume4
Issue number1
Pages (from-to)011002
ISSN1758-5082
Publication statusPublished - 2012
Externally publishedYes

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