Inconsistency in large pharmacogenomic studies

Benjamin Haibe-Kains; Nehme El-Hachem; Nicolai Juul Birkbak; Andrew C. Jin; Andrew H Beck; Hugo J. W. L. Aerts; John Quackenbush

doi:10.1038/nature12831

Inconsistency in large pharmacogenomic studies

Benjamin Haibe-Kains
, Nehme El-Hachem
, Nicolai Juul Birkbak
, Andrew C. Jin
, Andrew H Beck
, Hugo J. W. L. Aerts
, John Quackenbush

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.

Original language	English
Journal	Nature
Volume	504
Issue number	7480
Pages (from-to)	389–393
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature12831
Publication status	Published - 2013

Access to Document

10.1038/nature12831

OpenUrl availability

Full text

Cite this

@article{ff1c175433d84254b0e564e7d389abdb,

title = "Inconsistency in large pharmacogenomic studies",

abstract = "Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.",

author = "Benjamin Haibe-Kains and Nehme El-Hachem and Birkbak, \{Nicolai Juul\} and Jin, \{Andrew C.\} and Beck, \{Andrew H\} and Aerts, \{Hugo J. W. L.\} and John Quackenbush",

year = "2013",

doi = "10.1038/nature12831",

language = "English",

volume = "504",

pages = "389–393",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "7480",

}

TY - JOUR

T1 - Inconsistency in large pharmacogenomic studies

AU - Haibe-Kains, Benjamin

AU - El-Hachem, Nehme

AU - Birkbak, Nicolai Juul

AU - Jin, Andrew C.

AU - Beck, Andrew H

AU - Aerts, Hugo J. W. L.

AU - Quackenbush, John

PY - 2013

Y1 - 2013

N2 - Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.

AB - Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.

U2 - 10.1038/nature12831

DO - 10.1038/nature12831

M3 - Journal article

C2 - 24284626

SN - 0028-0836

VL - 504

SP - 389

EP - 393

JO - Nature

JF - Nature

IS - 7480

ER -

Inconsistency in large pharmacogenomic studies

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this