Inconsistency in large pharmacogenomic studies

Benjamin Haibe-Kains, Nehme El-Hachem, Nicolai Juul Birkbak, Andrew C. Jin, Andrew H Beck, Hugo J. W. L. Aerts, John Quackenbush

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.
    Original languageEnglish
    JournalNature
    Volume504
    Issue number7480
    Pages (from-to)389–393
    ISSN0028-0836
    DOIs
    Publication statusPublished - 2013

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