Incidence of high-level evernimicin resistance in Enterococcus faecium among food animals and humans

Frank Møller Aarestrup, P. M. McNicholas

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Six high-level evernimicin-resistant Enterococcus faecium isolates were identified among 304 avilarnycin-resistant E. faecium isolates from animals and 404 stool samples from humans with diarrhea. All four animal isolates, and one of the human isolates, were able to transfer resistance to a susceptible E. faecium strain. The resulting transconjugants all tested positive for the presence of emtA, a gene encoding a methyltransferase previously linked with high-level evernimicin resistance. The four transconjugants derived from animal isolates all carried the same plasmid, while a differently sized plasmid was found in the isolate from humans. This study demonstrated a low incidence of high-level evernimicin resistance mediated by the emtA gene in different E. faecium isolates of animal and human origin.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number9
Pages (from-to)3088-3090
ISSN0066-4804
DOIs
Publication statusPublished - 2002

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