In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Henrik Gutte; Adam E Hansen; Majbrit M E Larsen; Sofie Rahbek; Helle H Johannesen; Jan Henrik Ardenkjær-Larsen; Annemarie T Kristensen; Liselotte Højgaard; Andreas  Kjær

doi:10.3390/diagnostics5030287

In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Henrik Gutte
, Adam E Hansen
, Majbrit M E Larsen
, Sofie Rahbek
, Helle H Johannesen
, Jan Henrik Ardenkjær-Larsen
, Annemarie T Kristensen
, Liselotte Højgaard
, Andreas Kjær

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect in all tumors.

Original language	English
Journal	Diagnostics
Volume	5
Issue number	3
Pages (from-to)	287–289
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics5030287
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

13C-pyruvate
18F-FDG-PET
MR
PET/MR
Cancer
Dynamic nuclear polarization
HyperPET
Hyperpolarized
Molecular imaging

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10.3390/diagnostics5030287

Diagnostics 05 00287Final published version, 677 KB

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Gutte, H., Hansen, A. E., Larsen, M. M. E., Rahbek, S., Johannesen, H. H., Ardenkjær-Larsen, J. H., Kristensen, A. T., Højgaard, L., & Kjær, A. (2015). In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. Diagnostics, 5(3), 287–289. https://doi.org/10.3390/diagnostics5030287

Gutte, Henrik ; Hansen, Adam E ; Larsen, Majbrit M E et al. / In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. In: Diagnostics. 2015 ; Vol. 5, No. 3. pp. 287–289.

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title = "In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect",

abstract = "In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect in all tumors. ",

keywords = "13C-pyruvate, 18F-FDG-PET, MR, PET/MR, Cancer, Dynamic nuclear polarization, HyperPET, Hyperpolarized, Molecular imaging",

author = "Henrik Gutte and Hansen, \{Adam E\} and Larsen, \{Majbrit M E\} and Sofie Rahbek and Johannesen, \{Helle H\} and Ardenkj{\ae}r-Larsen, \{Jan Henrik\} and Kristensen, \{Annemarie T\} and Liselotte H{\o}jgaard and Andreas Kj{\ae}r",

year = "2015",

doi = "10.3390/diagnostics5030287",

language = "English",

volume = "5",

pages = "287–289",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Gutte, H, Hansen, AE, Larsen, MME, Rahbek, S, Johannesen, HH, Ardenkjær-Larsen, JH, Kristensen, AT, Højgaard, L & Kjær, A 2015, 'In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect', Diagnostics, vol. 5, no. 3, pp. 287–289. https://doi.org/10.3390/diagnostics5030287

In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. / Gutte, Henrik; Hansen, Adam E; Larsen, Majbrit M E et al.
In: Diagnostics, Vol. 5, No. 3, 2015, p. 287–289.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

AU - Gutte, Henrik

AU - Hansen, Adam E

AU - Larsen, Majbrit M E

AU - Rahbek, Sofie

AU - Johannesen, Helle H

AU - Ardenkjær-Larsen, Jan Henrik

AU - Kristensen, Annemarie T

AU - Højgaard, Liselotte

AU - Kjær, Andreas

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AB - In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect in all tumors.

KW - 13C-pyruvate

KW - 18F-FDG-PET

KW - MR

KW - PET/MR

KW - Cancer

KW - Dynamic nuclear polarization

KW - HyperPET

KW - Hyperpolarized

KW - Molecular imaging

U2 - 10.3390/diagnostics5030287

DO - 10.3390/diagnostics5030287

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JO - Diagnostics

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Gutte H, Hansen AE, Larsen MME, Rahbek S, Johannesen HH, Ardenkjær-Larsen JH et al. In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. Diagnostics. 2015;5(3):287–289. doi: 10.3390/diagnostics5030287