In vivo monitoring of angiogenesis within Matrigel chambers using MRI

David Holm; Carsten Dan Ley; Lise Vejby Søgaard; Helle Juhl Simonsen; Paul E. Krisjansen; Eva Løbner Lund; Ian John Rowland

In vivo monitoring of angiogenesis within Matrigel chambers using MRI

David Holm, Carsten Dan Ley, Lise Vejby Søgaard, Helle Juhl Simonsen, Paul E. Krisjansen, Eva Løbner Lund, Ian John Rowland

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Abstract

Angiogenesis is a critical process in tumour development and presents an important target for the development of a range of anti-cancer agents . To assess the in vivo efficacy of these ‘angiotherapeutics', a simple and reproducible in vivo model would be of significant value. Here we show that a gel containing pro-angiogenic agents held within a chamber may be positioned sub-cutaneously in mice and the angiogenic process followed using MR methods. This approach allows an individual animal to be followed with time in order to study the initial development of vasculature within the chambers.

Original language	English
Title of host publication	International Society for Magnetic Resonance in Medicine, MR of Cancer Study Group Workshop
Publication date	2006
Publication status	Published - 2006

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title = "In vivo monitoring of angiogenesis within Matrigel chambers using MRI",

abstract = "Angiogenesis is a critical process in tumour development and presents an important target for the development of a range of anti-cancer agents . To assess the in vivo efficacy of these {\textquoteleft}angiotherapeutics', a simple and reproducible in vivo model would be of significant value. Here we show that a gel containing pro-angiogenic agents held within a chamber may be positioned sub-cutaneously in mice and the angiogenic process followed using MR methods. This approach allows an individual animal to be followed with time in order to study the initial development of vasculature within the chambers.",

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author = "David Holm and Ley, {Carsten Dan} and S{\o}gaard, {Lise Vejby} and Simonsen, {Helle Juhl} and Krisjansen, {Paul E.} and Lund, {Eva L{\o}bner} and Rowland, {Ian John}",

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AU - Holm, David

AU - Ley, Carsten Dan

AU - Søgaard, Lise Vejby

AU - Simonsen, Helle Juhl

AU - Krisjansen, Paul E.

AU - Lund, Eva Løbner

AU - Rowland, Ian John

PY - 2006

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N2 - Angiogenesis is a critical process in tumour development and presents an important target for the development of a range of anti-cancer agents . To assess the in vivo efficacy of these ‘angiotherapeutics', a simple and reproducible in vivo model would be of significant value. Here we show that a gel containing pro-angiogenic agents held within a chamber may be positioned sub-cutaneously in mice and the angiogenic process followed using MR methods. This approach allows an individual animal to be followed with time in order to study the initial development of vasculature within the chambers.

AB - Angiogenesis is a critical process in tumour development and presents an important target for the development of a range of anti-cancer agents . To assess the in vivo efficacy of these ‘angiotherapeutics', a simple and reproducible in vivo model would be of significant value. Here we show that a gel containing pro-angiogenic agents held within a chamber may be positioned sub-cutaneously in mice and the angiogenic process followed using MR methods. This approach allows an individual animal to be followed with time in order to study the initial development of vasculature within the chambers.

KW - bolus

KW - MRI

KW - matrigel

KW - angiogenesis

KW - cancer

M3 - Article in proceedings

BT - International Society for Magnetic Resonance in Medicine, MR of Cancer Study Group Workshop

ER -