In vivo monitoring of angiogenesis within Matrigel chambers using MRI

David Holm, Carsten Dan Ley, Lise Vejby Søgaard, Helle Juhl Simonsen, Paul E. Krisjansen, Eva Løbner Lund, Ian John Rowland

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    Angiogenesis is a critical process in tumour development and presents an important target for the development of a range of anti-cancer agents . To assess the in vivo efficacy of these ‘angiotherapeutics', a simple and reproducible in vivo model would be of significant value. Here we show that a gel containing pro-angiogenic agents held within a chamber may be positioned sub-cutaneously in mice and the angiogenic process followed using MR methods. This approach allows an individual animal to be followed with time in order to study the initial development of vasculature within the chambers.
    Original languageEnglish
    Title of host publicationInternational Society for Magnetic Resonance in Medicine, MR of Cancer Study Group Workshop
    Publication date2006
    Publication statusPublished - 2006

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