In vivo fluorine biocatalysis: Six enzymes in search of a cell factory

Pablo I. Nikel; Ditte H. Welner; Antonin Cros; Daniel C. Volke

doi:10.1016/j.checat.2022.10.007

In vivo fluorine biocatalysis: Six enzymes in search of a cell factory

Pablo I. Nikel, Ditte H. Welner, Antonin Cros, Daniel C. Volke^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

In this Activity article, Pablo I. Nikel, Ditte H. Welner (senior researchers and group leaders), Antonin Cros (PhD student), Daniel Volke (tenure-track researcher) at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, discuss the need of expanding catalysis in vivo for organofluorine biosynthesis. Building on the inherent advantages of soil bacteria from the genus Pseudomonas, the authors also contend that P. putida could be an ideal platform to host the six enzymes that convert mineral fluoride into fluorinated building-blocks to pave the way to fluorine biocatalysis.

Original language	English
Journal	Chem Catalysis
Volume	2
Issue number	10
Pages (from-to)	2403-2405
Number of pages	3
ISSN	2667-1107
DOIs	https://doi.org/10.1016/j.checat.2022.10.007
Publication status	Published - 20 Oct 2022

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title = "In vivo fluorine biocatalysis: Six enzymes in search of a cell factory",

abstract = "In this Activity article, Pablo I. Nikel, Ditte H. Welner (senior researchers and group leaders), Antonin Cros (PhD student), Daniel Volke (tenure-track researcher) at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, discuss the need of expanding catalysis in vivo for organofluorine biosynthesis. Building on the inherent advantages of soil bacteria from the genus Pseudomonas, the authors also contend that P. putida could be an ideal platform to host the six enzymes that convert mineral fluoride into fluorinated building-blocks to pave the way to fluorine biocatalysis.",

author = "Nikel, {Pablo I.} and Welner, {Ditte H.} and Antonin Cros and Volke, {Daniel C.}",

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T2 - Six enzymes in search of a cell factory

AU - Nikel, Pablo I.

AU - Welner, Ditte H.

AU - Cros, Antonin

AU - Volke, Daniel C.

PY - 2022/10/20

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N2 - In this Activity article, Pablo I. Nikel, Ditte H. Welner (senior researchers and group leaders), Antonin Cros (PhD student), Daniel Volke (tenure-track researcher) at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, discuss the need of expanding catalysis in vivo for organofluorine biosynthesis. Building on the inherent advantages of soil bacteria from the genus Pseudomonas, the authors also contend that P. putida could be an ideal platform to host the six enzymes that convert mineral fluoride into fluorinated building-blocks to pave the way to fluorine biocatalysis.

AB - In this Activity article, Pablo I. Nikel, Ditte H. Welner (senior researchers and group leaders), Antonin Cros (PhD student), Daniel Volke (tenure-track researcher) at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, discuss the need of expanding catalysis in vivo for organofluorine biosynthesis. Building on the inherent advantages of soil bacteria from the genus Pseudomonas, the authors also contend that P. putida could be an ideal platform to host the six enzymes that convert mineral fluoride into fluorinated building-blocks to pave the way to fluorine biocatalysis.

U2 - 10.1016/j.checat.2022.10.007

DO - 10.1016/j.checat.2022.10.007

M3 - Comment/debate

AN - SCOPUS:85140290600

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VL - 2

SP - 2403

EP - 2405

JO - Chem Catalysis

JF - Chem Catalysis

IS - 10

ER -

In vivo fluorine biocatalysis: Six enzymes in search of a cell factory

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