In vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

J.-H. Jeon, V. Tejedor, S. Burov, E. Barkai, C. Selhuber-Unkel, Kirstine Berg-Sørensen, L. Oddershede, R. Metzler

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.
Original languageEnglish
JournalPhysical Review Letters
Volume106
Pages (from-to)048103
ISSN0031-9007
DOIs
Publication statusPublished - 2011

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