In vivo 3D Super-Resolution Ultrasound Imaging of a Rat Kidney using a Row-Column Array

Iman Taghavi, Mikkel Schou, Nathalie Sarup Panduro, Sofie Bech Andersen, Borislav G. Tomov, Charlotte Mehlin Sorensen, Matthias Bo Stuart, Jørgen Arendt Jensen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


Super-resolution ultrasound imaging (SRI) is a widely used technique for visualization of the microvasculature. The technique generally relies on long observation times if the smallest vessels have to be resolved. This makes it impractical for 3D imaging due to the large amounts of data required. Especially, matrix probes suffer from this, as the channel count is typically above 1024, which results in either a limited acquisition time or a greatly reduced frame rate. This work investigated the feasibility of using a row-column array (RCA) for 3D SRI. The 3D vascular tree of a Sprague Dawley rat kidney was imaged in a 26×26×40 mm3 volume using only 128 active elements in receive for a 6 MHz 128+128 Vermon RCA connected to a Verasonics Vantage 256™ scanner. Forty eight virtual sources with an amplitude modulated sequences were used to acquire 36 seconds of contrast-enhanced volumes. The data rate was 2.74 GBytes/s. Then, the 3D visualization of the vasculature was provided by localization of peaks in the acquired volumes. The estimated resolution using Fourier shell correlation for the reconstructed vasculature in this volume was 43 µm with half-bit and 61 µm with one-bit threshold, which was a factor of 6 below the wavelength (λ = 256 µm). In conclusion, the study showed the feasibility of super-resolution vascular imaging of a rat kidney using a RCA.
Original languageEnglish
Title of host publicationProceedings of 2022 IEEE International Ultrasonics Symposium (IUS)
Number of pages3
Publication date2022
ISBN (Print)978-1-6654-7813-7
ISBN (Electronic)978-1-6654-6657-8
Publication statusPublished - 2022
Event2022 IEEE International Ultrasonics Symposium - Venice, Italy
Duration: 10 Oct 202213 Oct 2022


Conference2022 IEEE International Ultrasonics Symposium


  • Contrast-enhanced ultrasound (CEUS)
  • Superresolution imaging (SRI)
  • Ultrasound localization microscopy (ULM)
  • Volumetric imaging
  • 3D imaging


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