A new off-line multiangle ultrasound (US) compound scanner has been built with the purpose of investigating possible improvements in visualization of vascular structure. Images of two formalin-fixed human atherosclerotic plaques removed by carotid endarterectomy were recorded from seven insonification angles over a range of 42 degrees and the individual images were combined (averaged) into a single image (spatial compounding). Compared to conventional B-mode imaging, this multiangle compound imaging (MACI) method features images with reduced angle-dependence, reduced random variation (speckle) and improved delineation of the plaque outline. With the MACI approach, it is, thus, easier to assess e.g., a possible residual lumen of an atherosclerotic artery as well as the level of echogenicity for the different plaque constituents. (C) 2000 World Federation for Ultrasound in Medicine & Biology.