In Situ Scanning Probe Microscopy and New Perspectives in Analytical Chemistry

Jens Enevold Thaulov Andersen, Jingdong Zhang, Qijin Chi, Allan Glargaard Hansen, Jens Ulrik Nielsen, Esben P. Friis, Jens Ulstrup, Anja Boisen, Henriette Jensenius

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The resolution of scanning probe microscopies is unpresedented but the techniques are fraught with limitations as analytical tools. These limitations and their relationship to the physical mechanisms of image contrast are first discussed. Some new options based on in situ STM, which hold prospects for molecular- and mesoscopic-scale analytical chemistry, are then reviewed. They are illustrated by metallic electro-crystallisation and -dissolution, and in situ STM spectroscopy of large redox molecules. The biophysically oriented analytical options of in situ atomic force microscopy, and analytical chemical perspectives for the new microcantilever sensor techniques are also discussed.
Original languageEnglish
JournalTrends in Analytical Chemistry
Issue number11
Pages (from-to)665-674
Publication statusPublished - 1999

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