In-house validation of a method for determination of silver nanoparticles in chicken meat based on asymmetric flow field-flow fractionation and inductively coupled plasma mass spectrometric detection

Katrin Löschner, Jana Navratilova, Ringo Grombe, Thomas P.J. Linsinger, Carsten Købler, Kristian Mølhave, Erik Huusfeldt Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Nanomaterials are increasingly used in food production and packaging, and validated methods for detection of nanoparticles (NPs) in foodstuffs need to be developed both for regulatory purposes and product development. Asymmetric flow field-flow fractionation with inductively coupled plasma mass spectrometric detection (AF4-ICP-MS) was applied for quantitative analysis of silver nanoparticles (AgNPs) in a chicken meat matrix following enzymatic sample preparation. For the first time an analytical validation of nanoparticle detection in a food matrix by AF4-ICP-MS has been carried out and the results showed repeatable and intermediately reproducible determination of AgNP mass fraction and size. The findings demonstrated the potential of AF4-ICP-MS for quantitative analysis of NPs in complex food matrices for use in food monitoring and control. The accurate determination of AgNP size distribution remained challenging due to the lack of certified size standards.
Original languageEnglish
JournalFood Chemistry
Volume181
Pages (from-to)78-84
Number of pages7
ISSN0308-8146
DOIs
Publication statusPublished - 2015

Keywords

  • Enzymatic digestion
  • Field-flow fractionation
  • Silver nanoparticles
  • Single particle ICP-MS
  • Validation
  • Animals
  • Flow fields
  • Fractionation
  • Inductively coupled plasma
  • Inductively coupled plasma mass spectrometry
  • Liquid chromatography
  • Mass spectrometers
  • Meats
  • Nanoparticles
  • Product development
  • Spectrometry
  • Enzymatic digestions
  • Field flow fractionation
  • Single particle
  • Silver

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