Improving substance information in usetox®, part 2: Data for estimating fate and ecosystem exposure factors

Erwan  Saouter; Karin Aschberger; Peter Fantke; Michael Zwicky Hauschild; Aude Kienzler; Alicia Paini; Rana Pant; Anita Radovnikovic; Michela Secchi; Serenella  Sala

doi:10.1002/etc.3903

Improving substance information in usetox®, part 2: Data for estimating fate and ecosystem exposure factors

Erwan Saouter, Karin Aschberger, Peter Fantke, Michael Zwicky Hauschild, Aude Kienzler, Alicia Paini, Rana Pant, Anita Radovnikovic, Michela Secchi, Serenella Sala

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The scientific consensus model USEtox® is developed since 2003 under the auspices of the UNEP-SETAC Life Cycle Initiative as a harmonized approach for characterizing human and freshwater toxicity in life cycle assessment (LCA) and other comparative assessment frameworks. Using physicochemical substance properties, USEtox® quantifies potential human toxicity and freshwater ecotoxicity impacts by combining environmental fate, exposure and toxicity effects information, considering multimedia fate and multi-pathway exposure processes. The main source to obtain substance properties for USEtox® 1.01 and 2.0 is the Estimation Program Interface (EPI SuiteTM ) from the U.S. Environmental Protection Agency. However, since the development of the original USEtox® substance databases, new chemical regulations have been enforced in Europe such as the REACH and the Plant Protection Products regulations. These regulations require that a chemical risk assessment for humans and the environment is performed before a chemical is placed on the European market. Consequently, additional physicochemical property data and new toxicological end-points are now available for thousands of chemical substances. The aim of the present study is to explore to which extent the new available data can be used as input for USEtox® - especially for application in Environmental Footprint studies - and to discuss how this would influence the quantification of fate and exposure factors. Initial results show that the choice of data source and the parameters selected can greatly influence fate and exposure factors leading to potentially different rankings and relative contributions of substances to overall human toxicity and ecotoxicity impacts. Moreover, it is crucial to discuss the relevance of exposure factor for freshwater ecotoxicity impacts particularly for persistent highly adsorbing and bio-accumulating substances. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Environmental Toxicology and Chemistry
Volume	36
Issue number	12
Pages (from-to)	3463–3470
ISSN	0730-7268
DOIs	https://doi.org/10.1002/etc.3903
Publication status	Published - 2017

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Saouter, Erwan ; Aschberger, Karin ; Fantke, Peter ; Hauschild, Michael Zwicky ; Kienzler, Aude ; Paini, Alicia ; Pant, Rana ; Radovnikovic, Anita ; Secchi, Michela ; Sala, Serenella . / Improving substance information in usetox®, part 2: Data for estimating fate and ecosystem exposure factors. In: Environmental Toxicology and Chemistry. 2017 ; Vol. 36, No. 12. pp. 3463–3470.

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title = "Improving substance information in usetox{\textregistered}, part 2: Data for estimating fate and ecosystem exposure factors",

abstract = "The scientific consensus model USEtox{\textregistered} is developed since 2003 under the auspices of the UNEP-SETAC Life Cycle Initiative as a harmonized approach for characterizing human and freshwater toxicity in life cycle assessment (LCA) and other comparative assessment frameworks. Using physicochemical substance properties, USEtox{\textregistered} quantifies potential human toxicity and freshwater ecotoxicity impacts by combining environmental fate, exposure and toxicity effects information, considering multimedia fate and multi-pathway exposure processes. The main source to obtain substance properties for USEtox{\textregistered} 1.01 and 2.0 is the Estimation Program Interface (EPI SuiteTM ) from the U.S. Environmental Protection Agency. However, since the development of the original USEtox{\textregistered} substance databases, new chemical regulations have been enforced in Europe such as the REACH and the Plant Protection Products regulations. These regulations require that a chemical risk assessment for humans and the environment is performed before a chemical is placed on the European market. Consequently, additional physicochemical property data and new toxicological end-points are now available for thousands of chemical substances. The aim of the present study is to explore to which extent the new available data can be used as input for USEtox{\textregistered} - especially for application in Environmental Footprint studies - and to discuss how this would influence the quantification of fate and exposure factors. Initial results show that the choice of data source and the parameters selected can greatly influence fate and exposure factors leading to potentially different rankings and relative contributions of substances to overall human toxicity and ecotoxicity impacts. Moreover, it is crucial to discuss the relevance of exposure factor for freshwater ecotoxicity impacts particularly for persistent highly adsorbing and bio-accumulating substances. This article is protected by copyright. All rights reserved.",

author = "Erwan Saouter and Karin Aschberger and Peter Fantke and Hauschild, {Michael Zwicky} and Aude Kienzler and Alicia Paini and Rana Pant and Anita Radovnikovic and Michela Secchi and Serenella Sala",

year = "2017",

doi = "10.1002/etc.3903",

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volume = "36",

pages = "3463–3470",

journal = "Environmental Toxicology and Chemistry",

issn = "0730-7268",

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Improving substance information in usetox®, part 2: Data for estimating fate and ecosystem exposure factors. / Saouter, Erwan ; Aschberger, Karin; Fantke, Peter ; Hauschild, Michael Zwicky; Kienzler, Aude; Paini, Alicia; Pant, Rana; Radovnikovic, Anita; Secchi, Michela; Sala, Serenella .

In: Environmental Toxicology and Chemistry, Vol. 36, No. 12, 2017, p. 3463–3470.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Improving substance information in usetox®, part 2: Data for estimating fate and ecosystem exposure factors

AU - Saouter, Erwan

AU - Aschberger, Karin

AU - Fantke, Peter

AU - Hauschild, Michael Zwicky

AU - Kienzler, Aude

AU - Paini, Alicia

AU - Pant, Rana

AU - Radovnikovic, Anita

AU - Secchi, Michela

AU - Sala, Serenella

PY - 2017

Y1 - 2017

N2 - The scientific consensus model USEtox® is developed since 2003 under the auspices of the UNEP-SETAC Life Cycle Initiative as a harmonized approach for characterizing human and freshwater toxicity in life cycle assessment (LCA) and other comparative assessment frameworks. Using physicochemical substance properties, USEtox® quantifies potential human toxicity and freshwater ecotoxicity impacts by combining environmental fate, exposure and toxicity effects information, considering multimedia fate and multi-pathway exposure processes. The main source to obtain substance properties for USEtox® 1.01 and 2.0 is the Estimation Program Interface (EPI SuiteTM ) from the U.S. Environmental Protection Agency. However, since the development of the original USEtox® substance databases, new chemical regulations have been enforced in Europe such as the REACH and the Plant Protection Products regulations. These regulations require that a chemical risk assessment for humans and the environment is performed before a chemical is placed on the European market. Consequently, additional physicochemical property data and new toxicological end-points are now available for thousands of chemical substances. The aim of the present study is to explore to which extent the new available data can be used as input for USEtox® - especially for application in Environmental Footprint studies - and to discuss how this would influence the quantification of fate and exposure factors. Initial results show that the choice of data source and the parameters selected can greatly influence fate and exposure factors leading to potentially different rankings and relative contributions of substances to overall human toxicity and ecotoxicity impacts. Moreover, it is crucial to discuss the relevance of exposure factor for freshwater ecotoxicity impacts particularly for persistent highly adsorbing and bio-accumulating substances. This article is protected by copyright. All rights reserved.

AB - The scientific consensus model USEtox® is developed since 2003 under the auspices of the UNEP-SETAC Life Cycle Initiative as a harmonized approach for characterizing human and freshwater toxicity in life cycle assessment (LCA) and other comparative assessment frameworks. Using physicochemical substance properties, USEtox® quantifies potential human toxicity and freshwater ecotoxicity impacts by combining environmental fate, exposure and toxicity effects information, considering multimedia fate and multi-pathway exposure processes. The main source to obtain substance properties for USEtox® 1.01 and 2.0 is the Estimation Program Interface (EPI SuiteTM ) from the U.S. Environmental Protection Agency. However, since the development of the original USEtox® substance databases, new chemical regulations have been enforced in Europe such as the REACH and the Plant Protection Products regulations. These regulations require that a chemical risk assessment for humans and the environment is performed before a chemical is placed on the European market. Consequently, additional physicochemical property data and new toxicological end-points are now available for thousands of chemical substances. The aim of the present study is to explore to which extent the new available data can be used as input for USEtox® - especially for application in Environmental Footprint studies - and to discuss how this would influence the quantification of fate and exposure factors. Initial results show that the choice of data source and the parameters selected can greatly influence fate and exposure factors leading to potentially different rankings and relative contributions of substances to overall human toxicity and ecotoxicity impacts. Moreover, it is crucial to discuss the relevance of exposure factor for freshwater ecotoxicity impacts particularly for persistent highly adsorbing and bio-accumulating substances. This article is protected by copyright. All rights reserved.

U2 - 10.1002/etc.3903

DO - 10.1002/etc.3903

M3 - Journal article

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VL - 36

SP - 3463

EP - 3470

JO - Environmental Toxicology and Chemistry

JF - Environmental Toxicology and Chemistry

SN - 0730-7268

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ER -