Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

Stine Egebro Hansen; Laura Serioli; Valentina Cavallo; Janus Anders Juul Haagensen; Søren Molin; Kinga Zor; Line Hagner Nielsen; Anja Boisen

Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

Stine Egebro Hansen, Laura Serioli, Valentina Cavallo, Janus Anders Juul Haagensen, Søren Molin, Kinga Zor, Line Hagner Nielsen, Anja Boisen

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Abstract

Treatment of biofilm-related infections often fails as antibiotics cannot be dosed in concentrations that
are sufficient to eradicate a bacterial biofilm. We have recently found that by using microcontainers
functionalized with chitosan, we can eradicate P. aeruginosa biofilms with substantially lower
antibiotic concentration [1]. N-acetylcysteine (NAC) is a mucolytic agent that promotes disruption of
mature biofilms [2]. This study aims to characterize NAC/chitosan-functionalized microcontainers and
investigate whether this combination could provide disruption of the mucin-containing biofilm matrix,
thereby improving bacterial susceptibility towards antibiotics and ultimately biofilm eradication.

Original language	English
Publication date	2020
Number of pages	3
Publication status	Published - 2020
Event	2020 CRS Annual Meeting & Exposition - Virtual Duration: 29 Jun 2020 → 2 Jul 2020

Conference

Conference	2020 CRS Annual Meeting & Exposition
Location	Virtual
Period	29/06/2020 → 02/07/2020

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Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers
Birk, S. E. (Speaker), Serioli Øland, L. (Other), Cavallo, V. (Other), Haagensen, J. A. J. (Other), Molin, S. (Other), Zor, K. (Other), Nielsen, L. H. (Other) & Boisen, A. (Other)
29 Jun 2020 → 2 Jul 2020
Activity: Talks and presentations › Conference presentations

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title = "Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers",

abstract = "Treatment of biofilm-related infections often fails as antibiotics cannot be dosed in concentrations thatare sufficient to eradicate a bacterial biofilm. We have recently found that by using microcontainersfunctionalized with chitosan, we can eradicate P. aeruginosa biofilms with substantially lowerantibiotic concentration [1]. N-acetylcysteine (NAC) is a mucolytic agent that promotes disruption ofmature biofilms [2]. This study aims to characterize NAC/chitosan-functionalized microcontainers andinvestigate whether this combination could provide disruption of the mucin-containing biofilm matrix,thereby improving bacterial susceptibility towards antibiotics and ultimately biofilm eradication.",

author = "Hansen, {Stine Egebro} and Laura Serioli and Valentina Cavallo and Haagensen, {Janus Anders Juul} and S{\o}ren Molin and Kinga Zor and Nielsen, {Line Hagner} and Anja Boisen",

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TY - ABST

T1 - Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

AU - Hansen, Stine Egebro

AU - Serioli, Laura

AU - Cavallo, Valentina

AU - Haagensen, Janus Anders Juul

AU - Molin, Søren

AU - Zor, Kinga

AU - Nielsen, Line Hagner

AU - Boisen, Anja

PY - 2020

Y1 - 2020

N2 - Treatment of biofilm-related infections often fails as antibiotics cannot be dosed in concentrations thatare sufficient to eradicate a bacterial biofilm. We have recently found that by using microcontainersfunctionalized with chitosan, we can eradicate P. aeruginosa biofilms with substantially lowerantibiotic concentration [1]. N-acetylcysteine (NAC) is a mucolytic agent that promotes disruption ofmature biofilms [2]. This study aims to characterize NAC/chitosan-functionalized microcontainers andinvestigate whether this combination could provide disruption of the mucin-containing biofilm matrix,thereby improving bacterial susceptibility towards antibiotics and ultimately biofilm eradication.

AB - Treatment of biofilm-related infections often fails as antibiotics cannot be dosed in concentrations thatare sufficient to eradicate a bacterial biofilm. We have recently found that by using microcontainersfunctionalized with chitosan, we can eradicate P. aeruginosa biofilms with substantially lowerantibiotic concentration [1]. N-acetylcysteine (NAC) is a mucolytic agent that promotes disruption ofmature biofilms [2]. This study aims to characterize NAC/chitosan-functionalized microcontainers andinvestigate whether this combination could provide disruption of the mucin-containing biofilm matrix,thereby improving bacterial susceptibility towards antibiotics and ultimately biofilm eradication.

M3 - Conference abstract for conference

T2 - 2020 CRS Annual Meeting & Exposition

Y2 - 29 June 2020 through 2 July 2020

ER -

Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

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Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

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