Improving antibiotic treatment of Pseudomonas aeruginosa biofilms using N-acetylcysteine-functionalized microcontainers

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Abstract

Treatment of biofilm-related infections often fails as antibiotics cannot be dosed in concentrations that
are sufficient to eradicate a bacterial biofilm. We have recently found that by using microcontainers
functionalized with chitosan, we can eradicate P. aeruginosa biofilms with substantially lower
antibiotic concentration [1]. N-acetylcysteine (NAC) is a mucolytic agent that promotes disruption of
mature biofilms [2]. This study aims to characterize NAC/chitosan-functionalized microcontainers and
investigate whether this combination could provide disruption of the mucin-containing biofilm matrix,
thereby improving bacterial susceptibility towards antibiotics and ultimately biofilm eradication.
Original languageEnglish
Publication date2020
Number of pages3
Publication statusPublished - 2020
Event2020 CRS Annual Meeting & Exposition - Virtual
Duration: 29 Jun 20202 Jul 2020

Conference

Conference2020 CRS Annual Meeting & Exposition
LocationVirtual
Period29/06/202002/07/2020

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