Improved Targeting of Cancers with Nanotherapeutics

Christian Foster, Andre Watson, Joseph John Kaplinsky, Nazila Kamaly

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    Abstract

    Targeted cancer nanotherapeutics offers numerous opportunities for the selective uptake of toxic chemotherapies within tumors and cancer cells. The unique properties of nanoparticles, such as their small size, large surface-to-volume ratios, and the ability to achieve multivalency of targeting ligands on their surface, provide superior advantages for nanoparticle-based drug delivery to a variety of cancers. This review highlights various key concepts in the design of targeted nanotherapeutics for cancer therapy, and discusses physicochemical parameters affecting nanoparticle targeting, along with recent developments for cancer-targeted nanomedicines.
    Original languageEnglish
    Title of host publicationCancer nanotechnology: Methods and Protocols
    EditorsReema Zeineldin
    Number of pages2
    Volume1530
    PublisherSpringer
    Publication date2017
    Pages13-37
    Chapter2
    ISBN (Print)978-1-4939-6644-8
    ISBN (Electronic)978-1-4939-6646-2
    DOIs
    Publication statusPublished - 2017
    SeriesMethods in Molecular Biology
    ISSN1064-3745

    Keywords

    • Targeting
    • Antibodies
    • Ligands
    • EPR
    • Cancer
    • Oncology
    • Nanoparticles
    • Nanotherapeutics
    • Nanomedicine
    • Multivalency
    • Drug delivery
    • Translation

    Cite this

    Foster, C., Watson, A., Kaplinsky, J. J., & Kamaly, N. (2017). Improved Targeting of Cancers with Nanotherapeutics. In R. Zeineldin (Ed.), Cancer nanotechnology: Methods and Protocols (Vol. 1530, pp. 13-37). Springer. Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-6646-2_2