Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reduction

Mette Mogensen, Thomas Martini Jørgensen, Lars Thrane, Birgit Meinecke Nurnberg, Gregor Borut Ernst Jemec

Research output: Contribution to journalJournal articleResearchpeer-review

301 Downloads (Pure)

Abstract

BACKGROUND: Optical coherence tomography (OCT) is a possible imaging method for delineation of non-melanoma skin cancer. Speckle noise is the dominant noise contribution in OCT images; it limits the ability to identify cellular structures especially skin cancer. QUESTIONS ADDRESSED: This report suggests a method for improving OCT image quality for skin cancer imaging. EXPERIMENTAL DESIGN: OCT is an optical imaging method analogous to ultrasound. Two basal cell carcinomas (BCC) were imaged using an OCT speckle reduction technique (SR-OCT) based on repeated scanning by altering the distance between the probe and the surface of the skin. RESULTS: SR-OCT resulted in improved visualisation and more accurate thickness measurements in BCC lesions. CONCLUSION: This OCT speckle reduction method led to improved visualisation and better defined delineations in two BCC lesions. Thus, OCT was improved to a clinically relevant level when imaging BCC lesions.
Original languageEnglish
JournalExperimental Dermatology
Volume19
Issue number8
Pages (from-to)e293-e295
ISSN0906-6705
DOIs
Publication statusPublished - 2010

Keywords

  • Optical coherence tomography speckle
  • Basal cell carcinoma

Fingerprint Dive into the research topics of 'Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reduction'. Together they form a unique fingerprint.

Cite this