Improved methods to determine radionuclidic purity of F-18 compounds

Thomas Jørgensen; Mille Ankerstjerne Micheelsen; Mikael Jensen

doi:10.1016/j.apradiso.2011.10.012

Improved methods to determine radionuclidic purity of F-18 compounds

Thomas Jørgensen
, Mille Ankerstjerne Micheelsen
, Mikael Jensen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.

Original language	English
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	3
Pages (from-to)	430-437
ISSN	0969-8043
DOIs	https://doi.org/10.1016/j.apradiso.2011.10.012
Publication status	Published - 2012

Keywords

CHEMISTRY
NUCLEAR
RADIOLOGY,

Access to Document

10.1016/j.apradiso.2011.10.012

OpenUrl availability

Check availability in DTU Findit

Cite this

@article{ec0c503d6b094780822d421a0c11d6ef,

title = "Improved methods to determine radionuclidic purity of F-18 compounds",

abstract = "Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9\%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5\% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.",

keywords = "CHEMISTRY, NUCLEAR, RADIOLOGY,",

author = "Thomas J{\o}rgensen and Micheelsen, \{Mille Ankerstjerne\} and Mikael Jensen",

year = "2012",

doi = "10.1016/j.apradiso.2011.10.012",

language = "English",

volume = "70",

pages = "430--437",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Improved methods to determine radionuclidic purity of F-18 compounds

AU - Jørgensen, Thomas

AU - Micheelsen, Mille Ankerstjerne

AU - Jensen, Mikael

PY - 2012

Y1 - 2012

N2 - Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.

AB - Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.

KW - CHEMISTRY

KW - NUCLEAR

KW - RADIOLOGY,

U2 - 10.1016/j.apradiso.2011.10.012

DO - 10.1016/j.apradiso.2011.10.012

M3 - Journal article

C2 - 22104500

SN - 0969-8043

VL - 70

SP - 430

EP - 437

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 3

ER -

Improved methods to determine radionuclidic purity of F-18 compounds

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this