Improved methods to determine radionuclidic purity of F-18 compounds

Thomas Jørgensen, Mille Ankerstjerne Micheelsen, Mikael Jensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    JournalApplied Radiation and Isotopes
    Volume70
    Issue number3
    Pages (from-to)430-437
    ISSN0969-8043
    DOIs
    Publication statusPublished - 2012

    Keywords

    • CHEMISTRY
    • NUCLEAR
    • RADIOLOGY,

    Fingerprint Dive into the research topics of 'Improved methods to determine radionuclidic purity of F-18 compounds'. Together they form a unique fingerprint.

    Cite this