Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

J. W. Helge; B. Stallknecht; Tue Drachmann; Lars Hellgren; R. Jimenez-Jimenez; J. L. Andersen; B. Richelsen; J. M. Bruun

doi:10.1111/j.1748-1716.2010.02180.x

Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

J. W. Helge
, B. Stallknecht
, Tue Drachmann
, Lars Hellgren
, R. Jimenez-Jimenez
, J. L. Andersen
, B. Richelsen
, J. M. Bruun

Aarhus University Hospital
Copenhagen University Hospital Herlev and Gentofte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Aim: This study investigated the effect of a 15-week life style intervention (hypocaloric diet and regular exercise) on glucose tolerance, skeletal muscle lipids and muscle metabolic adaptations in 14 female and 9 male morbidly obese subjects (age: 32.5 +/- 2.3 years, BMI: 46.1 +/- 1.9 kg m(-2)). Method: Before and after the life style intervention an oral glucose tolerance test (OGTT) was performed and a muscle biopsy was obtained in the fasted state. Maximal oxygen uptake was measured by an indirect test. Results: After the intervention body weight was decreased (P

Original language	English
Journal	Acta Physiologica (Print)
Volume	201
Issue number	3
Pages (from-to)	357-364
ISSN	1748-1708
DOIs	https://doi.org/10.1111/j.1748-1716.2010.02180.x
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Obesity
Weight loss
Insulin resistance

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10.1111/j.1748-1716.2010.02180.x

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Helge, J. W., Stallknecht, B., Drachmann, T., Hellgren, L., Jimenez-Jimenez, R., Andersen, J. L., Richelsen, B., & Bruun, J. M. (2011). Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects. Acta Physiologica (Print), 201(3), 357-364. https://doi.org/10.1111/j.1748-1716.2010.02180.x

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title = "Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects",

abstract = "Aim: This study investigated the effect of a 15-week life style intervention (hypocaloric diet and regular exercise) on glucose tolerance, skeletal muscle lipids and muscle metabolic adaptations in 14 female and 9 male morbidly obese subjects (age: 32.5 +/- 2.3 years, BMI: 46.1 +/- 1.9 kg m(-2)). Method: Before and after the life style intervention an oral glucose tolerance test (OGTT) was performed and a muscle biopsy was obtained in the fasted state. Maximal oxygen uptake was measured by an indirect test. Results: After the intervention body weight was decreased (P",

keywords = "Obesity, Weight loss, Insulin resistance",

author = "Helge, \{J. W.\} and B. Stallknecht and Tue Drachmann and Lars Hellgren and R. Jimenez-Jimenez and Andersen, \{J. L.\} and B. Richelsen and Bruun, \{J. M.\}",

year = "2011",

doi = "10.1111/j.1748-1716.2010.02180.x",

language = "English",

volume = "201",

pages = "357--364",

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Helge, JW, Stallknecht, B, Drachmann, T, Hellgren, L, Jimenez-Jimenez, R, Andersen, JL, Richelsen, B & Bruun, JM 2011, 'Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects', Acta Physiologica (Print), vol. 201, no. 3, pp. 357-364. https://doi.org/10.1111/j.1748-1716.2010.02180.x

TY - JOUR

T1 - Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

AU - Helge, J. W.

AU - Stallknecht, B.

AU - Drachmann, Tue

AU - Hellgren, Lars

AU - Jimenez-Jimenez, R.

AU - Andersen, J. L.

AU - Richelsen, B.

AU - Bruun, J. M.

PY - 2011

Y1 - 2011

N2 - Aim: This study investigated the effect of a 15-week life style intervention (hypocaloric diet and regular exercise) on glucose tolerance, skeletal muscle lipids and muscle metabolic adaptations in 14 female and 9 male morbidly obese subjects (age: 32.5 +/- 2.3 years, BMI: 46.1 +/- 1.9 kg m(-2)). Method: Before and after the life style intervention an oral glucose tolerance test (OGTT) was performed and a muscle biopsy was obtained in the fasted state. Maximal oxygen uptake was measured by an indirect test. Results: After the intervention body weight was decreased (P

AB - Aim: This study investigated the effect of a 15-week life style intervention (hypocaloric diet and regular exercise) on glucose tolerance, skeletal muscle lipids and muscle metabolic adaptations in 14 female and 9 male morbidly obese subjects (age: 32.5 +/- 2.3 years, BMI: 46.1 +/- 1.9 kg m(-2)). Method: Before and after the life style intervention an oral glucose tolerance test (OGTT) was performed and a muscle biopsy was obtained in the fasted state. Maximal oxygen uptake was measured by an indirect test. Results: After the intervention body weight was decreased (P

KW - Obesity

KW - Weight loss

KW - Insulin resistance

U2 - 10.1111/j.1748-1716.2010.02180.x

DO - 10.1111/j.1748-1716.2010.02180.x

M3 - Journal article

C2 - 20726847

SN - 1748-1708

VL - 201

SP - 357

EP - 364

JO - Acta Physiologica (Print)

JF - Acta Physiologica (Print)

IS - 3

ER -

Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

Abstract

UN SDGs

Keywords

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