Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

J. W. Helge, B. Stallknecht, Tue Drachmann, Lars Hellgren, R. Jimenez-Jimenez, J. L. Andersen, B. Richelsen, J. M. Bruun

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Aim: This study investigated the effect of a 15-week life style intervention (hypocaloric diet and regular exercise) on glucose tolerance, skeletal muscle lipids and muscle metabolic adaptations in 14 female and 9 male morbidly obese subjects (age: 32.5 +/- 2.3 years, BMI: 46.1 +/- 1.9 kg m(-2)). Method: Before and after the life style intervention an oral glucose tolerance test (OGTT) was performed and a muscle biopsy was obtained in the fasted state. Maximal oxygen uptake was measured by an indirect test. Results: After the intervention body weight was decreased (P
    Original languageEnglish
    JournalActa Physiologica (Print)
    Volume201
    Issue number3
    Pages (from-to)357-364
    ISSN1748-1708
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Obesity
    • Weight loss
    • Insulin resistance

    Fingerprint Dive into the research topics of 'Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects'. Together they form a unique fingerprint.

    Cite this