Improved biosensor-based detection system

Peter Rugbjerg (Inventor), Hans Jasper Genee (Inventor), Morten Otto Alexander Sommer (Inventor)

Research output: Patent

267 Downloads (Pure)

Abstract

Described is a new biosensor-based detection system for effector compounds, useful for in vivo applications in e.g. screening and selecting of cells which produce a small molecule effector compound or which take up a small molecule effector compound from its environment. The detection system comprises a protein or RNA-based biosensor for the effector compound which indirectly regulates the expression of a reporter gene via two hybrid proteins, providing for fewer false signals or less 'noise', tuning of sensitivity or other advantages over conventional systems where the biosensor directly regulates the reporter gene.

Original languageEnglish
IPCC12Q 1/ 68 A I
Patent numberWO2015044456
Filing date02/04/2015
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date30/09/2013
Priority numberEP20130186673
Publication statusPublished - 2 Apr 2015

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