Impact of the gut microbiota on chemical risk assessment

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

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Impact of the gut microbiota on chemical risk assessment. / Licht, Tine Rask; Bahl, Martin Iain.

In: Current Opinion in Toxicology, 2019.

Research output: Contribution to journalJournal article – Annual report year: 2019Researchpeer-review

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@article{543d403c84524611b7baa1bc5077f4ab,
title = "Impact of the gut microbiota on chemical risk assessment",
abstract = "It is well established that the multitude of microbes residing in the human intestine play a key role for health. Recently, it has become apparent that ingested chemicals affect the composition of the human gut microbiota. Additionally, the gut microbes affect the uptake and metabolism of chemicals in multiple ways. Here, we outline the current knowledge about the complex interplay between gut microbes, ingested xenobiotics and toxicological effects. We propose that the intestinal microbiota plays a key role in chemical toxicity, which is typically overlooked in existing approaches for risk assessment. This means that factors such as animal provider, batch/litter differences, and co-caging may significantly influence the outcome of toxicity evaluations based on rodent experiments.The effect of ingested chemicals may be significantly influenced by the gut microbiota of individual experimental animals. This should be considered in toxicological risk assessment.",
keywords = "Risk assessment, Intestinal microbiota, Gut permeability, Microbial metabolism of chemicals",
author = "Licht, {Tine Rask} and Bahl, {Martin Iain}",
year = "2019",
doi = "10.1016/j.cotox.2018.09.004",
language = "English",
journal = "Current Opinion in Toxicology",
issn = "2468-2020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Impact of the gut microbiota on chemical risk assessment

AU - Licht, Tine Rask

AU - Bahl, Martin Iain

PY - 2019

Y1 - 2019

N2 - It is well established that the multitude of microbes residing in the human intestine play a key role for health. Recently, it has become apparent that ingested chemicals affect the composition of the human gut microbiota. Additionally, the gut microbes affect the uptake and metabolism of chemicals in multiple ways. Here, we outline the current knowledge about the complex interplay between gut microbes, ingested xenobiotics and toxicological effects. We propose that the intestinal microbiota plays a key role in chemical toxicity, which is typically overlooked in existing approaches for risk assessment. This means that factors such as animal provider, batch/litter differences, and co-caging may significantly influence the outcome of toxicity evaluations based on rodent experiments.The effect of ingested chemicals may be significantly influenced by the gut microbiota of individual experimental animals. This should be considered in toxicological risk assessment.

AB - It is well established that the multitude of microbes residing in the human intestine play a key role for health. Recently, it has become apparent that ingested chemicals affect the composition of the human gut microbiota. Additionally, the gut microbes affect the uptake and metabolism of chemicals in multiple ways. Here, we outline the current knowledge about the complex interplay between gut microbes, ingested xenobiotics and toxicological effects. We propose that the intestinal microbiota plays a key role in chemical toxicity, which is typically overlooked in existing approaches for risk assessment. This means that factors such as animal provider, batch/litter differences, and co-caging may significantly influence the outcome of toxicity evaluations based on rodent experiments.The effect of ingested chemicals may be significantly influenced by the gut microbiota of individual experimental animals. This should be considered in toxicological risk assessment.

KW - Risk assessment

KW - Intestinal microbiota

KW - Gut permeability

KW - Microbial metabolism of chemicals

U2 - 10.1016/j.cotox.2018.09.004

DO - 10.1016/j.cotox.2018.09.004

M3 - Journal article

JO - Current Opinion in Toxicology

JF - Current Opinion in Toxicology

SN - 2468-2020

ER -