Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae

Jens Nielsen, Michael Christopher Jewett

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Industrial biotechnology is a rapidly growing field. With the increasing shift towards a bio-based economy, there is rising demand for developing efficient cell factories that can produce fuels, chemicals, pharmaceuticals, materials, nutraceuticals, and even food ingredients. The yeast Saccharomyces cerevisiae is extremely well suited for this objective. As one of the most intensely studied eukaryotic model organisms, a rich density of knowledge detailing its genetics, biochemistry, physiology, and large-scale fermentation performance can be capitalized upon to enable a substantial increase in the industrial application of this yeast. Developments in genomics and high-throughput systems biology tools are enhancing one's ability to rapidly characterize cellular behaviour, which is valuable in the field of metabolic engineering where strain characterization is often the bottleneck in strain development programmes. Here, the impact of systems biology on metabolic engineering is reviewed and perspectives on the role of systems biology in the design of cell factories are given.
    Original languageEnglish
    JournalFEMS Yeast Research
    Volume8
    Issue number1
    Pages (from-to)122-131
    ISSN1567-1356
    DOIs
    Publication statusPublished - 2008

    Keywords

    • model
    • systems biology
    • industrial biotechnology
    • metabolic engineering
    • cell factory
    • Saccharomyces cerevisiae

    Fingerprint Dive into the research topics of 'Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae'. Together they form a unique fingerprint.

    Cite this