Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals

David Jullesson, Florian David, Brian Pfleger, Jens Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.
Original languageEnglish
JournalBiotechnology Advances
Volume33
Issue number7
Pages (from-to)1395-1402
Number of pages8
ISSN0734-9750
DOIs
Publication statusPublished - 2015

Keywords

  • Cell factories
  • Escherichia coli
  • Industrial production
  • Metabolic engineering
  • Saccharomyces cerevisiae
  • Synthetic biology

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