Impact Of Mutation-derived Antigens In Immune Recognition Of Hematological Malignancies, Specifically Myeloid Dysplastic Syndromes (MDS)

Research output: Contribution to journalConference abstract in journal – Annual report year: 2016Researchpeer-review

View graph of relations

Mutation-derived neoepitopes have been suggested as a major component for immune recognition of solid tumors with a high mutational load, e.g. Melanoma and Non-Small-Cell Lung Cancer (NSCLC). Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by increasing bone marrow failure due to clonal expansion of immature dysplastic cells in the bone marrow. Compared to Melanoma and NSCLC, these dysplastic cells carry low numbers of point mutations, but high levels of frameshifts, indels, splice variations or epigenetic changes. All of which may contribute to the generation of tumor-specific neoepitopes.
Original languageEnglish
Article numberP237
JournalHaematologica
Volume101
Issue numberS1
Pages (from-to)66-66
Number of pages1
ISSN0390-6078
Publication statusPublished - 2016
Event21st Congress of the European Hematology Association - Copenhagen, Denmark
Duration: 9 Jun 201612 Jun 2016
http://www.ehaweb.org/congress-and-events/21st-congress/key-information-3/

Conference

Conference21st Congress of the European Hematology Association
CountryDenmark
CityCopenhagen
Period09/06/201612/06/2016
Internet address

ID: 125754846