Impact Of Mutation-derived Antigens In Immune Recognition Of Hematological Malignancies, Specifically Myeloid Dysplastic Syndromes (MDS)

Mutation-derived neoepitopes have been suggested as a major component for immune recognition of solid tumors with a high mutational load, e.g. Melanoma and Non-Small-Cell Lung Cancer (NSCLC). Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by increasing bone marrow failure due to clonal expansion of immature dysplastic cells in the bone marrow. Compared to Melanoma and NSCLC, these dysplastic cells carry low numbers of point mutations, but high levels of frameshifts, indels, splice variations or epigenetic changes. All of which may contribute to the generation of tumor-specific neoepitopes.