Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8(+) T cells

Britta Strehl, Thorsten Joeris, Melanie Rieger, Alexander Visekruna, Kathrin Textoris-Taube, Stefan H. E. Kaufmann, Peter-Michael Kloetzel, Ulrike Kuckelkorn, Ulrich Steinhoff

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Microbial infections induce the replacement of constitutive proteasomes by immunoproteasomes (I-proteasomes). I-proteasomes support efficient generation of MHC class I epitopes and influence immunodominance hierarchies of CD8(+) T cells. Recently, the function of I-proteasomes in antimicrobial responses was challenged by showing that the lack of I-proteasomes has no effect on induction and function of lymphocytic choriomeningitis virus-specific CD8(+) T cells. Here, we show that infection with Listeria monocytogenes rapidly induces I-proteasomes in nonlymphoid tissues, which leads to enhanced generation of protection relevant CD8(+) T cell epitopes. I-proteasome-deficient mice (beta 5i(-/-) mice) exhibited normal frequencies of L monocytogenes-specific CD8(+) T cells. However, clearance of L. monocytogenes in liver but not spleen was significantly impaired in I-proteasome-deficient mice. In summary, our studies demonstrate that induction of I-proteasomes is required for CD8(+) T cell-mediated elimination of L monocytogenes from nonlymphoid but not lymphoid tissues.
Original languageEnglish
JournalJournal of Immunology
Volume177
Issue number9
Pages (from-to)6238-6244
Number of pages7
ISSN0022-1767
Publication statusPublished - 2006
Externally publishedYes

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