ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

F. Pappalardo, M. D. Halling-Brown, Nicolas Rapin, Ping Zhang, D. Alemani, A. Emerson, P. Paci, P. Duroux, M. Pennisi, A. Palladini, O. Miotto, D. Churchill, E. Rossi, A. J. Shepherd, D. S. Moss, F. Castiglione, M. Bernaschi, M. P. Lefranc, Søren Brunak, S. MottaP. L. Lollini, K. E. Basford, V. Brusic

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at http://www.w3.org.
    Original languageEnglish
    JournalBriefings in Bioinformatics
    Volume10
    Issue number3
    Pages (from-to)330-340
    ISSN1467-5463
    DOIs
    Publication statusPublished - 2009

    Keywords

    • vaccine discovery
    • immunoinformatics
    • Grid computing
    • computational modeling
    • simulations

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