Abstract
Rainbow trout fry of average weight 0.5 g were vaccinated against viral haemorrhagic septicaemia (VHS) by intramuscular injection of 1 mug of plasmid DNA encoding the VHS virus glycoprotein gene. Challenge with a lethal dose of virus at two different time points, 9 and 71 days post-vaccination respectively, revealed that a highly protective and lasting immunity was established shortly after vaccination, in accordance with earlier experiments with larger fish. The defence mechanisms activated by the DNA vaccine are thus functional at an early life-stage in rainbow trout.
| Original language | English |
|---|---|
| Journal | Fish & shellfish immunology |
| Volume | 11 |
| Issue number | 7 |
| Pages (from-to) | 585-591 |
| ISSN | 1050-4648 |
| DOIs | |
| Publication status | Published - 2001 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- genetic immunisation
- rainbow trout fry
- plasmid DNA
- rhabdovirus
- early immunity
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