Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage

Niels Lorenzen, Ellen Lorenzen, Katja Einer-Jensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Rainbow trout fry of average weight 0.5 g were vaccinated against viral haemorrhagic septicaemia (VHS) by intramuscular injection of 1 mug of plasmid DNA encoding the VHS virus glycoprotein gene. Challenge with a lethal dose of virus at two different time points, 9 and 71 days post-vaccination respectively, revealed that a highly protective and lasting immunity was established shortly after vaccination, in accordance with earlier experiments with larger fish. The defence mechanisms activated by the DNA vaccine are thus functional at an early life-stage in rainbow trout.
    Original languageEnglish
    JournalFish & shellfish immunology
    Volume11
    Issue number7
    Pages (from-to)585-591
    ISSN1050-4648
    DOIs
    Publication statusPublished - 2001

    Keywords

    • genetic immunisation
    • rainbow trout fry
    • plasmid DNA
    • rhabdovirus
    • early immunity

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