Immunity to gastrointestinal nematode infections

D. Sorobetea, M. Svensson Frej, R. Grencis*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals and humans, with over a billion of the world's population infected with at least one species. These large multicellular pathogens present a considerable and complex challenge to the host immune system given that individuals are continually exposed to infective stages, as well as the high prevalence in endemic areas. This review summarizes our current understanding of host-parasite interactions, detailing induction of protective immunity, mechanisms of resistance, and resolution of the response. It is clear from studies of well-defined laboratory model systems that these responses are dominated by innate and adaptive type 2 cytokine responses, regulating cellular and soluble effectors that serve to disrupt the niche in which the parasites live by strengthening the physical mucosal barrier and ultimately promoting tissue repair.
    Original languageEnglish
    JournalMucosal Immunology
    Volume11
    Issue number2
    Pages (from-to)304-315
    ISSN1933-0219
    DOIs
    Publication statusPublished - 2018

    Bibliographical note

    This work is licensed under a Creative Commons Attribution 4.0 International License

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