Immune epitope database analysis resource

Yohan Kim, Julia Ponomarenko, Zhanyang Zhu, Dorjee Tamang, Peng Wang, Jason Greenbaum, Claus Lundegaard, Alessandro Sette, Ole Lund, Philip E. Bourne, Morten Nielsen, Bjoern Peters

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    Abstract

    The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
    Original languageEnglish
    JournalNucleic Acids Research
    Volume40
    Issue numberW1
    Pages (from-to)W525-W530
    ISSN0305-1048
    DOIs
    Publication statusPublished - 2012

    Keywords

    • immune epitope database analysis resource
    • immune response
    • MHC-I
    • MHC-II
    • peptide
    • 00530, General biology - Information, documentation, retrieval and computer applications
    • 02506, Cytology - Animal
    • 10064, Biochemistry studies - Proteins, peptides and amino acids
    • 15002, Blood - Blood and lymph studies
    • 15004, Blood - Blood cell studies
    • 34502, Immunology - General and methods
    • Chemical Coordination and Homeostasis
    • Computational Biology
    • B-cell immune system, blood and lymphatics
    • T-cell immune system, blood and lymphatics
    • computer software package computer software
    • epitope prediction tool mathematical and computer techniques
    • homology mapping tool mathematical and computer techniques
    • Computer Applications
    • Immune System

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