Abstract
The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
| Original language | English |
|---|---|
| Journal | Nucleic Acids Research |
| Volume | 40 |
| Issue number | W1 |
| Pages (from-to) | W525-W530 |
| ISSN | 0305-1048 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- immune epitope database analysis resource
- immune response
- MHC-I
- MHC-II
- peptide
- 00530, General biology - Information, documentation, retrieval and computer applications
- 02506, Cytology - Animal
- 10064, Biochemistry studies - Proteins, peptides and amino acids
- 15002, Blood - Blood and lymph studies
- 15004, Blood - Blood cell studies
- 34502, Immunology - General and methods
- Chemical Coordination and Homeostasis
- Computational Biology
- B-cell immune system, blood and lymphatics
- T-cell immune system, blood and lymphatics
- computer software package computer software
- epitope prediction tool mathematical and computer techniques
- homology mapping tool mathematical and computer techniques
- Computer Applications
- Immune System