Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

Yong-Ming Wang, Zhuo-Ya Yang, Xin-Lu Cai, Han-Yu Zhou, Rui-Ting Zhang, Han-Xue Yang, Yun-Si Liang, Xiong-Zhao Zhu, Kristoffer Hougaard Madsen, Thomas Alrik Sørensen, Arne Møller, Zhen Wang, Eric F C Cheung, Raymond C K Chan

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.
Original languageEnglish
JournalSchizophrenia Bulletin
Pages (from-to)1-12
Number of pages12
ISSN0586-7614
DOIs
Publication statusPublished - 2019

Keywords

  • Diffusion tensor imaging
  • Schizo-obsessive comorbidity
  • Schizophrenia
  • Obsessive-compulsive disorder
  • Support vector classification

Cite this

Wang, Yong-Ming ; Yang, Zhuo-Ya ; Cai, Xin-Lu ; Zhou, Han-Yu ; Zhang, Rui-Ting ; Yang, Han-Xue ; Liang, Yun-Si ; Zhu, Xiong-Zhao ; Madsen, Kristoffer Hougaard ; Sørensen, Thomas Alrik ; Møller, Arne ; Wang, Zhen ; Cheung, Eric F C ; Chan, Raymond C K. / Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography. In: Schizophrenia Bulletin. 2019 ; pp. 1-12.
@article{cb1009c065914f88a86f30a63a015235,
title = "Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography",
abstract = "A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.",
keywords = "Diffusion tensor imaging, Schizo-obsessive comorbidity, Schizophrenia, Obsessive-compulsive disorder, Support vector classification",
author = "Yong-Ming Wang and Zhuo-Ya Yang and Xin-Lu Cai and Han-Yu Zhou and Rui-Ting Zhang and Han-Xue Yang and Yun-Si Liang and Xiong-Zhao Zhu and Madsen, {Kristoffer Hougaard} and S{\o}rensen, {Thomas Alrik} and Arne M{\o}ller and Zhen Wang and Cheung, {Eric F C} and Chan, {Raymond C K}",
year = "2019",
doi = "10.1093/schbul/sbz073",
language = "English",
pages = "1--12",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

Wang, Y-M, Yang, Z-Y, Cai, X-L, Zhou, H-Y, Zhang, R-T, Yang, H-X, Liang, Y-S, Zhu, X-Z, Madsen, KH, Sørensen, TA, Møller, A, Wang, Z, Cheung, EFC & Chan, RCK 2019, 'Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography', Schizophrenia Bulletin, pp. 1-12. https://doi.org/10.1093/schbul/sbz073

Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography. / Wang, Yong-Ming; Yang, Zhuo-Ya; Cai, Xin-Lu; Zhou, Han-Yu; Zhang, Rui-Ting; Yang, Han-Xue; Liang, Yun-Si; Zhu, Xiong-Zhao; Madsen, Kristoffer Hougaard; Sørensen, Thomas Alrik; Møller, Arne; Wang, Zhen; Cheung, Eric F C; Chan, Raymond C K.

In: Schizophrenia Bulletin, 2019, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

AU - Wang, Yong-Ming

AU - Yang, Zhuo-Ya

AU - Cai, Xin-Lu

AU - Zhou, Han-Yu

AU - Zhang, Rui-Ting

AU - Yang, Han-Xue

AU - Liang, Yun-Si

AU - Zhu, Xiong-Zhao

AU - Madsen, Kristoffer Hougaard

AU - Sørensen, Thomas Alrik

AU - Møller, Arne

AU - Wang, Zhen

AU - Cheung, Eric F C

AU - Chan, Raymond C K

PY - 2019

Y1 - 2019

N2 - A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.

AB - A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.

KW - Diffusion tensor imaging

KW - Schizo-obsessive comorbidity

KW - Schizophrenia

KW - Obsessive-compulsive disorder

KW - Support vector classification

U2 - 10.1093/schbul/sbz073

DO - 10.1093/schbul/sbz073

M3 - Journal article

SP - 1

EP - 12

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

ER -