Identifying potential virulence determinants in viral haemorrhagic septicaemia virus (VHSV) for rainbow trout

Scott Campbell, Bertrand Collet, Katja Einer-Jensen, Chris J. Secombes, Mike Snow

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    We identified viral haemorrhagic septicaemia virus (VHSV) isolates classified within Genotype Ib which are genetically similar (>99.4% glycoprotein amino acid identity) yet, based on their isolation history, were suspected to differ in virulence in juvenile rainbow trout. The virulence of an isolate recovered in 2000 from a viral haemorrhagic septicaemia disease episode in a marine rainbow trout farm in Sweden (SE-SVA-1033) was evaluated in juvenile rainbow trout via intraperitoneal injection and immersion challenge alongside 3 isolates recovered from wild-caught marine fish (DK-4p37, DK-5e59 and UKMLA98/6HE1) suspected of being of low pathogenicity to trout. Mortality data revealed that isolate SE-SVA-1033 caused VHSV-specific mortality in both intraperitoneal and immersion challenges (75.0 and 15.4%, respectively). The remaining Genotype Ib isolates caused significantly lower mortalities using the same experimental infection routes (
    Original languageEnglish
    JournalDiseases of Aquatic Organisms
    Volume86
    Issue number3
    Pages (from-to)205-212
    ISSN0177-5103
    DOIs
    Publication statusPublished - 2009

    Keywords

    • VHSV
    • Rainbow trout
    • Pathogenicity
    • Sequencing
    • Virulence determinants

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