Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome

Karine Marie Laure Audouze, Anne Tromelin, Anne Marie Le Bon, Christine Belloir, Rasmus Koefoed Petersen, Karsten Kristiansen, Søren Brunak, Olivier Taboureau

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    The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors ( hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma ( PPAR gamma). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome.
    Original languageEnglish
    Article numbere93037
    JournalPLOS ONE
    Issue number4
    Number of pages12
    Publication statusPublished - 2014

    Bibliographical note

    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


    • Celery ketone
    • Citral
    • Citronellal
    • Fragrances
    • Isovaleric acid
    • Octanol
    • Oxoacid
    • Peroxisome proliferator activated receptor gamma
    • Propionic acid
    • Unclassified drug
    • Biological activity
    • Ligand binding
    • Molecular Modeling
    • Odorome
    • Olfactory discrimination
    • Olfactory receptor
    • Olfactory system
    • Protein protein interaction
    • Protein structure
    • Receptor binding

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