Abstract
Bushmasters (Lachesis spp) and lancehead vipers (Bothrops spp) are two of the most dangerous snakes found in Latin America. Victims of envenoming by these snakes require urgent administration of antivenom. Here, we report the identification of a small set of broadly neutralizing human monoclonal single-chain variable fragment (scFv) antibodies targeting key phospholipases A2 from Lachesis and Bothrops spp using phage display technology and demonstrate their in vitro efficacy using a hemolysis assay.
Original language | English |
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Journal | Toxicon |
Volume | 184 |
Pages (from-to) | 116-121 |
ISSN | 0041-0101 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Antivenom
- Monoclonal antibody
- Lechesis muta
- Bothrops spp
- Cross-reactive antibodies
- Phage display