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Identification of Bacterial Small RNAs by RNA Sequencing

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    Abstract

    Small regulatory RNAs (sRNAs) in bacteria are known to modulate gene expression and control a variety of processes including metabolic reactions, stress responses, and pathogenesis in response to environmental signals. A method to identify bacterial sRNAs on a genome-wide scale based on RNA sequencing (RNA-seq) is described that involves the preparation and analysis of three different sequencing libraries. As a signifi cant number of unique sRNAs are identifi ed in each library, the libraries can be used either alone or in combination to increase the number of sRNAs identifi ed. The approach may be applied to identify sRNAs in any bacterium under different growth and stress conditions.
    Original languageEnglish
    Title of host publicationPseudomonas Methods and Protocols
    EditorsAlain Filloux, Juan-Luis Ramos
    PublisherSpringer Science+Business Media
    Publication date2014
    Pages433-456
    ISBN (Print)ISBN 978-1-4939-0472-3
    DOIs
    Publication statusPublished - 2014
    SeriesMethods in Molecular Biology
    Volume1149
    ISSN1064-3745

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