Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals

M. F. Bertelsen, M. Kjelgaard-Hansen, C. Grøndahl, Peter M. H. Heegaard, S. Jacobsen

    Research output: Contribution to journalJournal articleResearchpeer-review


    The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of three potential APPs-serum amyloid A (SAA), C-reactive protein (CRP), and haptoglobin (Hp)-was evaluated in eight species. For SAA, a turbidimetric immunoassay (TIA) demonstrated significant detective abilities ill the Asian elephant (Elaphas maximus), impala (Aepyceros melampus), musk ox (Ovibos moschatus), and chimpanzee (Pan troglodytes), as did an SAA enzyme-linked immunosorbent assay (ELISA) in the impala. For CRP, both TIA and ELISA had significant detective abilities in the chimpanzee. For Hp, a colorimetric assay demonstrated significant detective abilities in impala, musk ox, sitatunga (Tragelaphus spekeii), and chimpanzee. as did the Hp ELISA in the impala, musk ox, and sitatunga. Ill Conclusion, these results suggest that assays for detection of relevant APPs in several nondomesticated animals are available.
    Original languageEnglish
    JournalJournal of Zoo and Wildlife Medicine
    Issue number1
    Pages (from-to)199-203
    Publication statusPublished - 2009


    • inflammation
    • haptoglobin
    • zoo animals
    • serum amyloid A
    • Acute phase response
    • C-reactive protein

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