Identification of a novel immunoregulatory signaling pathway exploited by M. tuberculosis in dendritic cells

Janne Marie Laursen, Erwin Schoof, Jonas Nørskov Søndergaard, Rune Linding, Susanne Brix Pedersen

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    Abstract

    The causative agent of tuberculosis, Mycobacterium tuberculosis, has infected over a third of the world's population and poses a massive burden to health care systems and human well-being. Most M. tuberculosis infections are latent and are not cleared fully by the host immune system due to the highly sophisticated infectious machinery employed by the bacterium. The dendritic cell (DC) plays a crucial role in shaping the nature of the immune response after exposure to pathogens, and the interaction between M. tuberculosis and the dendritic cell is of profound importance for the course of infection. During their interaction, the DC is exposed to multiple M. tuberculosis-derived ligands recognized by a range of pattern recognition receptors, but the result is typically an immune response that is not very effective at clearing the bacteria from the host. The reason why the induced immune response is ineffective at clearing the bacteria is not fully understood, but clues may be given in the signaling pathways induced in DCs upon M. tuberculosis-exposure.
    Original languageEnglish
    JournalScandinavian Journal of Immunology
    Volume77
    Issue number4
    Pages (from-to)284-285
    ISSN0300-9475
    DOIs
    Publication statusPublished - 2013
    Event41st Scandinavian Society of Immunology Meeting - København, Denmark
    Duration: 14 Apr 201317 Apr 2013

    Conference

    Conference41st Scandinavian Society of Immunology Meeting
    CountryDenmark
    CityKøbenhavn
    Period14/04/201317/04/2013

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