Identification and partial characterization of Taastrup virus: a newly identified member species of the Mononegavirales

J.O. Bock, T. Lundsgaard, P.A. Pedersen, Laurids Siig Christensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    We present a 8904-nt sequence of the central part of the RNA genome of a novel virus with a filovirus-like, nonidentical morphology named Taastrup Virus (TV) detected in the leafhopper Psammotettix alienus. Sequence analysis identified five potential open reading frames (ORFs) and a complex pattern of homologies to various members of the Mononegavirales suggests a genome organization with the following order of genes: 3'-N-P-M-G-L-5'. Sequence analyses reveal an unusually large glycoprotein (G) containing both potential O-linked (14) and N-linked (9) glycosylation sites-a feature shared with the glycoproteins of Filoviridae and Pneumovirinae, and a nucleoprotein (N) with homology to the nucleoprotein of viral hemorrhagic septicemia virus (VHSV), a member of the Rhabdoviridae. Highly conserved domains were identified in the RNA-dependent RNA polymerase (L) between TV and other viruses within the order of Mononegavirales, and homology was found in particular with members of the Rhabdoviridae. The sequence similarities and the unique filovirus-like but nonidentical morphology unambiguously refer this newly identified virus to the order of Mononegavirales but to no family more than any to other within the order.
    Original languageEnglish
    JournalVirology
    Volume319
    Issue number1
    Pages (from-to)49-59
    ISSN0042-6822
    DOIs
    Publication statusPublished - 2004

    Keywords

    • Taastrup virus
    • species
    • Mononegavirales

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