Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins

Gerald F. Bills, Qun Yue, Li Chen, Yan Li, Zhiqiang An, Jens Christian Frisvad

    Research output: Contribution to journalJournal articleResearchpeer-review


    The invalidly published name Aspergillus sydowii var. mulundensis was proposed for a strain of Aspergillus that produced new echinocandin metabolites designated as the mulundocadins. Reinvestigation of this strain (Y-30462=DSMZ 5745) using phylogenetic, morphological, and metabolic data indicated that it is a distinct and novel species of Aspergillus sect. Nidulantes. The taxonomic novelty, Aspergillus mulundensis, is introduced for this historically important echinocandin-producing strain. The closely related A. nidulans FGSC A4 has one of the most extensively characterized secondary metabolomes of any filamentous fungus. Comparison of the full-genome sequences of DSMZ 5745 and FGSC A4 indicated that the two strains share 33 secondary metabolite biosynthetic gene clusters. These shared gene clusters represent ~45% of the total secondary metabolome of each strain, thus indicating a high level intraspecific divergence in terms of secondary metabolism.
    Original languageEnglish
    JournalThe Journal of Antibiotics
    Issue number3
    Pages (from-to)141-148
    Number of pages8
    Publication statusPublished - 2016

    Fingerprint Dive into the research topics of '<i>Aspergillus mulundensis sp. nov.</i>, a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins'. Together they form a unique fingerprint.

    Cite this