Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Anders Elias Hansen; A.T. Kristensen; I. Law; J.T. Jørgensen; S.A. Engelholm

doi:10.1111/j.1476-5829.2010.00233.x

Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Anders Elias Hansen
, A.T. Kristensen
, I. Law
, J.T. Jørgensen
, S.A. Engelholm

University of Copenhagen
Copenhagen University Hospital Herlev and Gentofte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

Original language	English
Journal	Veterinary and Comparative Oncology
Volume	9
Issue number	1
Pages (from-to)	16-37
ISSN	1476-5810
DOIs	https://doi.org/10.1111/j.1476-5829.2010.00233.x
Publication status	Published - 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis",

abstract = "Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.",

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language = "English",

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TY - JOUR

T1 - Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

AU - Hansen, Anders Elias

AU - Kristensen, A.T.

AU - Law, I.

AU - Jørgensen, J.T.

AU - Engelholm, S.A.

PY - 2015

Y1 - 2015

N2 - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

AB - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

U2 - 10.1111/j.1476-5829.2010.00233.x

DO - 10.1111/j.1476-5829.2010.00233.x

M3 - Journal article

SN - 1476-5810

VL - 9

SP - 16

EP - 37

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

IS - 1

ER -

Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Abstract

UN SDGs

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