Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Anders Elias Hansen, A.T. Kristensen, I. Law, J.T. Jørgensen, S.A. Engelholm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.
Original languageEnglish
JournalVeterinary and Comparative Oncology
Volume9
Issue number1
Pages (from-to)16-37
ISSN1476-5810
DOIs
Publication statusPublished - 2015
Externally publishedYes

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