Hyperpolarized 13C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy

Christoffer Laustsen; Thomas Stokholm Nørlinger; David Christoffer Hansen; Haiyun Qi; Per Mose Nielsen; Lotte Bonde Bertelsen; Jan Henrik Ardenkjær-Larsen; Hans Stødkilde Jørgensen

doi:10.1002/mrm.26036

Hyperpolarized ¹³C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy

Christoffer Laustsen, Thomas Stokholm Nørlinger, David Christoffer Hansen, Haiyun Qi, Per Mose Nielsen, Lotte Bonde Bertelsen, Jan Henrik Ardenkjær-Larsen, Hans Stødkilde Jørgensen

Aarhus University

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Abstract

Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment was conducted in a group of streptozotocin type-1 diabetic rat model and age matched controls. Results: A significantly different relaxation time (P=0.004) was found in the diabetic kidney (0.49±0.03 s) compared with the controls (0.64±0.02 s) and secondly, a strong correlation between the blood oxygen saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations.

Original language	English
Journal	Magnetic Resonance in Medicine
Volume	75
Issue number	2
Pages (from-to)	515-518
ISSN	0740-3194
DOIs	https://doi.org/10.1002/mrm.26036
Publication status	Published - 2016

Keywords

Hyperpolarization
Kidney
MRI
Renal metabolism
Type 1 diabetes

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10.1002/mrm.26036

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title = "Hyperpolarized 13C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy",

abstract = "Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment was conducted in a group of streptozotocin type-1 diabetic rat model and age matched controls. Results: A significantly different relaxation time (P=0.004) was found in the diabetic kidney (0.49±0.03 s) compared with the controls (0.64±0.02 s) and secondly, a strong correlation between the blood oxygen saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations.",

keywords = "Hyperpolarization, Kidney, MRI, Renal metabolism, Type 1 diabetes",

author = "Christoffer Laustsen and {Stokholm N{\o}rlinger}, Thomas and {Christoffer Hansen}, David and Haiyun Qi and Nielsen, {Per Mose} and {Bonde Bertelsen}, Lotte and Ardenkj{\ae}r-Larsen, {Jan Henrik} and {St{\o}dkilde J{\o}rgensen}, Hans",

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T1 - Hyperpolarized 13C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy

AU - Laustsen, Christoffer

AU - Stokholm Nørlinger, Thomas

AU - Christoffer Hansen, David

AU - Qi, Haiyun

AU - Nielsen, Per Mose

AU - Bonde Bertelsen, Lotte

AU - Ardenkjær-Larsen, Jan Henrik

AU - Stødkilde Jørgensen, Hans

PY - 2016

Y1 - 2016

N2 - Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment was conducted in a group of streptozotocin type-1 diabetic rat model and age matched controls. Results: A significantly different relaxation time (P=0.004) was found in the diabetic kidney (0.49±0.03 s) compared with the controls (0.64±0.02 s) and secondly, a strong correlation between the blood oxygen saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations.

AB - Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment was conducted in a group of streptozotocin type-1 diabetic rat model and age matched controls. Results: A significantly different relaxation time (P=0.004) was found in the diabetic kidney (0.49±0.03 s) compared with the controls (0.64±0.02 s) and secondly, a strong correlation between the blood oxygen saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations.

KW - Hyperpolarization

KW - Kidney

KW - MRI

KW - Renal metabolism

KW - Type 1 diabetes

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