Hyperpolarized 13C Urea Relaxation Mechanism Reveals Renal Changes in Diabetic Nephropathy

Christoffer Laustsen, Thomas Stokholm Nørlinger, David Christoffer Hansen, Haiyun Qi, Per Mose Nielsen, Lotte Bonde Bertelsen, Jan Henrik Ardenkjær-Larsen, Hans Stødkilde Jørgensen

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Abstract

Purpose: Our aim was to assess a novel 13C radial fast spin echo golden ratio single shot method for interrogating early renal changes in the diabetic kidney, using hyperpolarized (HP) [13C,15N2]urea as a T2 relaxation based contrast bio-probe. Methods: A novel HP 13C MR contrast experiment was conducted in a group of streptozotocin type-1 diabetic rat model and age matched controls. Results: A significantly different relaxation time (P=0.004) was found in the diabetic kidney (0.49±0.03 s) compared with the controls (0.64±0.02 s) and secondly, a strong correlation between the blood oxygen saturation level and the relaxation times were observed in the healthy controls. Conclusion: HP [13C,15N2]urea apparent T2 mapping may be a useful for interrogating local renal pO2 status and renal tissue alterations.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume75
Issue number2
Pages (from-to)515-518
ISSN0740-3194
DOIs
Publication statusPublished - 2016

Keywords

  • Hyperpolarization
  • Kidney
  • MRI
  • Renal metabolism
  • Type 1 diabetes

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