Abstract
This study focuses on the formulation of three hyperpolarized metabolic contrast agents for large animal experiments: KIC, alanine and fumarate, hyperpolarized at high field to levels comparable to pyruvic acid. These substrates offer high concentration injectables, compatibility with biological systems, appropriate tissue distribution, and relevance to metabolic studies. We aim to enable investigations in brain energy metabolism in large animals and, potentially, humans.
| Original language | English |
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| Publication date | 2023 |
| Publication status | Published - 2023 |
| Event | International Hyperpolarization Conference 2024 - University of Leipzig, Leipzig, Germany Duration: 24 Sept 2023 → 28 Sept 2023 |
Conference
| Conference | International Hyperpolarization Conference 2024 |
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| Location | University of Leipzig |
| Country/Territory | Germany |
| City | Leipzig |
| Period | 24/09/2023 → 28/09/2023 |